Pre-fusion structure of a human coronavirus spike protein
Identifieur interne : 001068 ( Main/Exploration ); précédent : 001067; suivant : 001069Pre-fusion structure of a human coronavirus spike protein
Auteurs : Robert N. Kirchdoerfer [États-Unis] ; Christopher A. Cottrell [États-Unis] ; Nianshuang Wang ; Jesper Pallesen [États-Unis] ; Hadi M. Yassine ; Hannah L. Turner [États-Unis] ; Kizzmekia S. Corbett ; Barney S. Graham ; Jason S. Mclellan ; Andrew B. Ward [États-Unis]Source :
- Nature [ 0028-0836 ] ; 2016.
Descripteurs français
- KwdFr :
- Coronavirus (), Coronavirus (ultrastructure), Cryomicroscopie électronique, Fusion membranaire, Glycoprotéine de spicule des coronavirus (), Glycoprotéine de spicule des coronavirus (métabolisme), Glycoprotéine de spicule des coronavirus (ultrastructure), Humains, Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Multimérisation de protéines, Protéolyse, Pénétration virale, Récepteurs viraux (métabolisme), Sous-unités de protéines (), Sous-unités de protéines (métabolisme), Structure quaternaire des protéines, Structure tertiaire des protéines, Vaccins antiviraux (), Vaccins antiviraux (immunologie).
- MESH :
- immunologie : Vaccins antiviraux.
- métabolisme : Glycoprotéine de spicule des coronavirus, Récepteurs viraux, Sous-unités de protéines.
- Coronavirus, Cryomicroscopie électronique, Fusion membranaire, Glycoprotéine de spicule des coronavirus, Humains, Liaison aux protéines, Lignée cellulaire, Modèles moléculaires, Multimérisation de protéines, Protéolyse, Pénétration virale, Sous-unités de protéines, Structure quaternaire des protéines, Structure tertiaire des protéines, Vaccins antiviraux.
English descriptors
- KwdEn :
- Cell Line, Coronavirus (chemistry), Coronavirus (ultrastructure), Cryoelectron Microscopy, Humans, Membrane Fusion, Models, Molecular, Protein Binding, Protein Multimerization, Protein Structure, Quaternary, Protein Structure, Tertiary, Protein Subunits (chemistry), Protein Subunits (metabolism), Proteolysis, Receptors, Virus (metabolism), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (metabolism), Spike Glycoprotein, Coronavirus (ultrastructure), Viral Vaccines (chemistry), Viral Vaccines (immunology), Virus Internalization.
- MESH :
- chemical , chemistry : Protein Subunits, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- chemistry : Coronavirus.
- chemical , immunology : Viral Vaccines.
- chemical , metabolism : Protein Subunits, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- ultrastructure : Coronavirus, Spike Glycoprotein, Coronavirus.
- Cell Line, Cryoelectron Microscopy, Humans, Membrane Fusion, Models, Molecular, Protein Binding, Protein Multimerization, Protein Structure, Quaternary, Protein Structure, Tertiary, Proteolysis, Virus Internalization.
Abstract
A 4.0 Å resolution cryo-electron microscopy structure of the pre-fusion form of the trimeric spike from the human coronavirus HKU1 provides insight into how the spike protein mediates host-cell attachment and membrane fusion.
The online version of this article (doi:10.1038/nature17200) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nature17200
PubMed: 26935699
PubMed Central: 4860016
Affiliations:
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Line</term><term>Coronavirus (chemistry)</term><term>Coronavirus (ultrastructure)</term><term>Cryoelectron Microscopy</term><term>Humans</term><term>Membrane Fusion</term><term>Models, Molecular</term><term>Protein Binding</term><term>Protein Multimerization</term><term>Protein Structure, Quaternary</term><term>Protein Structure, Tertiary</term><term>Protein Subunits (chemistry)</term><term>Protein Subunits (metabolism)</term><term>Proteolysis</term><term>Receptors, Virus (metabolism)</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term><term>Spike Glycoprotein, Coronavirus (metabolism)</term><term>Spike Glycoprotein, Coronavirus (ultrastructure)</term><term>Viral Vaccines (chemistry)</term><term>Viral Vaccines (immunology)</term><term>Virus Internalization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus ()</term><term>Coronavirus (ultrastructure)</term><term>Cryomicroscopie électronique</term><term>Fusion membranaire</term><term>Glycoprotéine de spicule des coronavirus ()</term><term>Glycoprotéine de spicule des coronavirus (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus (ultrastructure)</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Multimérisation de protéines</term><term>Protéolyse</term><term>Pénétration virale</term><term>Récepteurs viraux (métabolisme)</term><term>Sous-unités de protéines ()</term><term>Sous-unités de protéines (métabolisme)</term><term>Structure quaternaire des protéines</term><term>Structure tertiaire des protéines</term><term>Vaccins antiviraux ()</term><term>Vaccins antiviraux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Protein Subunits</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protein Subunits</term><term>Receptors, Virus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycoprotéine de spicule des coronavirus</term><term>Récepteurs viraux</term><term>Sous-unités de protéines</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Coronavirus</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Cryoelectron Microscopy</term><term>Humans</term><term>Membrane Fusion</term><term>Models, Molecular</term><term>Protein Binding</term><term>Protein Multimerization</term><term>Protein Structure, Quaternary</term><term>Protein Structure, Tertiary</term><term>Proteolysis</term><term>Virus Internalization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coronavirus</term><term>Cryomicroscopie électronique</term><term>Fusion membranaire</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Liaison aux protéines</term><term>Lignée cellulaire</term><term>Modèles moléculaires</term><term>Multimérisation de protéines</term><term>Protéolyse</term><term>Pénétration virale</term><term>Sous-unités de protéines</term><term>Structure quaternaire des protéines</term><term>Structure tertiaire des protéines</term><term>Vaccins antiviraux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">A 4.0 Å resolution cryo-electron microscopy structure of the pre-fusion form of the trimeric spike from the human coronavirus HKU1 provides insight into how the spike protein mediates host-cell attachment and membrane fusion.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nature17200) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christian, Md" uniqKey="Christian M">MD Christian</name></author><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author><author><name sortKey="Loutfy, Mr" uniqKey="Loutfy M">MR Loutfy</name></author><author><name sortKey="Muller, Mp" uniqKey="Muller M">MP Muller</name></author><author><name sortKey="Low, De" uniqKey="Low D">DE Low</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van 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Corbett</name><name sortKey="Graham, Barney S" sort="Graham, Barney S" uniqKey="Graham B" first="Barney S." last="Graham">Barney S. Graham</name><name sortKey="Mclellan, Jason S" sort="Mclellan, Jason S" uniqKey="Mclellan J" first="Jason S." last="Mclellan">Jason S. Mclellan</name><name sortKey="Wang, Nianshuang" sort="Wang, Nianshuang" uniqKey="Wang N" first="Nianshuang" last="Wang">Nianshuang Wang</name><name sortKey="Yassine, Hadi M" sort="Yassine, Hadi M" uniqKey="Yassine H" first="Hadi M." last="Yassine">Hadi M. Yassine</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Kirchdoerfer, Robert N" sort="Kirchdoerfer, Robert N" uniqKey="Kirchdoerfer R" first="Robert N." last="Kirchdoerfer">Robert N. Kirchdoerfer</name></region><name sortKey="Cottrell, Christopher A" sort="Cottrell, Christopher A" uniqKey="Cottrell C" first="Christopher A." last="Cottrell">Christopher A. Cottrell</name><name sortKey="Pallesen, Jesper" sort="Pallesen, Jesper" uniqKey="Pallesen J" first="Jesper" last="Pallesen">Jesper Pallesen</name><name sortKey="Turner, Hannah L" sort="Turner, Hannah L" uniqKey="Turner H" first="Hannah L." last="Turner">Hannah L. Turner</name><name sortKey="Ward, Andrew B" sort="Ward, Andrew B" uniqKey="Ward A" first="Andrew B." last="Ward">Andrew B. Ward</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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